The 4sustainability Protocol is a system for the correct management of chemical substances aimed at gradually eliminating from production processes those toxic and harmful to human health and the environment. It is the result of a synthesis of what the most important brands in the world require of companies in the supply chain and their ability to respond. 4sustainability is the first Italian service provider accredited by ZDHC, which collaborates with the fashion brands and companies in the sector for a sustainable development. The elimination of hazardous chemicals is both an ambitious commitment and an essential opportunity of development. But how do we implement this change? For this reason, the Chemical Management 4sustainability Protocol has been created. It is a process that focuses on method, objectives and results.